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KMID : 0613820090190030362
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Journal of Life Science
2009 Volume.19 No. 3 p.362 ~ p.365
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Association of Hepatocyte Nuclear Factor-4α Polymorphisms with Type 2 Diabetes in Koreans
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Kim Su-Won
Yoo Min
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Abstract
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Type 2 diabetes is a typical polygenic disease complex, for which several common risk alleles have been identified. The hepatocyte nuclear factor-4α (HNF-4α), a transcription factor involved in the regulation of serum lipid and glucose levels, has recently been associated with type 2 diabetes. Therefore, we investigated the genotype for the C＞T polymorphism at position 12352 of the HNF-4α gene in Koreans and compared patient genotypes with those of the control group. 100 patients (63 males, 37 females) with a history of type 2 diabetes (T2DM) and 100 controls (36 males, 64 females) participated in this study. There was no association between 12352 C＞T polymorphism in the HNF-4α gene and T2DM. The present study shows that HNF-4α 12352 C＞T polymorphism may not be associated with the pathogenesis of T2DM. Further studies with larger populations may be needed for the development of diagnostic methods at a genetic level such as DNA chip.
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KEYWORD
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HNF-4α gene, polymorphism, type 2 diabetes, Korean
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